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Efek Pemberian Daun Mimba (Azadirachta indica) Terhadap Struktur Hepatosit Tikus (Rattus norvegicus)
ABSTRAK
Daun mimba (Azadirachta indica) diketahui sebagai senyawa antifertilitas. Daun
mimba mengandung senyawa flavonoid yang dapat menghambat kerusakan sel.
Penelitian ini bertujuan untuk menguji efek daun mimba (Azadirachta indica)
terhadap diameter hepatosit yang ditunjukkan dengan perubahan diameter hepatosit
tikus. Jumlah hewan uji dalam penelitian ini 12 ekor tikus putih jantan (Rattus
norvegicus). Penelitian ini dilakukan dengan menggunakan Rancangan Acak
Lengkap (RAL). Hewan diberi perlakuan PO, P1, P2 dan P3 masing-masing dengan
perlakuan ekstrak daun mimba dosis 12,16 dan 20 mg/ekor/hari. Pembuatan preparat
menggunakan pewarna Hematoxilin Eosin (HE) ketebalan sayatan 3-5 µ. Perlakuan
dilakukan selama 14 hari. Parameter yang diamati adalah diameter hepatosit,
diameter lobulus hepar, bobot badan akhir dan bobot hepar. Pengolahan data
dilakukan dengan menggunakan uji ANOVA. Semua analisis dilakukan dengan taraf
signifikansi 5% (α=0.05). Hasil penelitian menunjukkan pemberian ekstrak daun
mimba memberikan pengaruh tidak berbeda nyata (p>0,05) terhadap diameter
hepatosit, diameter lobulus hepar, bobot hepar dan bobot badan akhir. Kesimpulan
dari penelitian ini bahwa pemberian ekstrak ethanol daun mimba sampai dosis 20
mg/ekor/hari selama 14 hari tidak mempengaruhi terhadap diameter hepatosit,
diameter hepar, bobot hepar serta bobot badan akhir.
Kata kunci : Daun Mimba, Diameter Hepatosit, Rattus norvegicus
ABSTRACT
Neem leaf (Azadirachta indica) was known as infertility herb. Neem leaf contain of
flavonoid compounds which inhibit the damage of cell. This research aimed to
examine the effect of neem leaf on hepotocyte and liver lobules diameter. The total of
labolatory animals in this research were 12 male Rattus novergicus. This research was
conducted by using the Complete Randomized Design (CRD). The animal was
treated by neem leaf extracted with 12, 16, and 20 mg/animal/day (PO, P1, P2, P3)
respectively. The treatment was treated during 14 days. The liver was made as
histological slide by using HE stain with 3-4 µ in thickness. The observed parameters
were hepatocyte diameter, liver lobules diameter, the final body weight and liver
weight. Data here analyzed by ANOVA test. All the analysis were performed with
5% significant level. The results showed that the giving of neem leaf extract had no
significant effects (p>0.05) on hepatocyte diameter, liver lobules diameter, liver
weight and final body weight. It could be concluded that the giving of ethanolic neem
leaves extract with 20 mg/animal/day for 14 days did not affect the hepatocyte
diameter, liver diameter, liver weight and final body weight.
Keyword : Neem Leaves, Hepatocyte Diameter, Rattus norvegicus
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