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Pengaruh Pemberian Ekstrak Air Biji Pepaya (Carica papaya L.) Terhadap Struktur Intestinum Tenue Mencit (Mus musculus L.) Betina

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ABSTRAK
Ibnu Thoriq Hidayat.24020113130135. Pengaruh Pemberian Ekstrak Air Biji Pepaya
(Carica Papaya L.) Terhadap Stuktur Intestinum Tenue Mencit (Mus Musculus L.) Betina.
Di bawah bimbingan Agung Janika Sitasiwi dan Siti Miflichatun Mardiati
Ekstrak biji Pepaya (Carica papaya L.) mengandung saponin, alkaloid, flavonoid, dan tannin
biasa digunakan sebagai bahan obat tradisional. Ekstrak ethanol biji papaya menunjukkan reaksi
penghambatan pada kontraksi jejunum dan secara signifikan bersifat irreversible. Penelitian ini
bertujuan untuk menguji pengaruh pemberian ekstrak air biji pepaya terhadap struktur intestinum
mencit (Mus musculus L.). Penelitian ini menggunakan Rancangan Acak Lengkap dengan 4
perlakuan yaitu P0 (akuades), P1 (1,4 mg/0,5 ml), P2 (3,5 mg/0,5 ml) dan P3 (7 mg/0,5 ml).
Perlakuan dilakukan secara oral selama 21 hari. Pemberian pakan secara ad libitum. Intestinum
tenue diisolasi sepanjang 2 cm dari lambung sepanjang 1 cm kemudian di buat sediaan histologis
dengan metode paraffin dengan tebal sayatan 5 µm dan pewarnaan Hemaktosilin dan Eosin
(H&E). Pengukuran panjang vili dan diameter intestinum tenue dilakukan pada 3 sayatan di
setiap 3 sediaan histologis intestinum tenue. Data dianalisis dengan uji Anova, dilanjutkan
dengan uji Duncan dengan taraf signifikansi 5%. Hasil analisis menunjukkan paparan bahan uji
tidak perpengaruh signifikan (p>0,05) terhadap diameter intestinum, panjang vili, dan bobot
badan. Penelitian ini dapat disimpulkan bahwa pemberian ekstrak air biji pepaya selama 21 hari
tidak mempengaruhi struktur intestinum tenue mencit sehingga aman digunakan sebagai bahan
obat.
Kata kunci: Carica papaya, vili, intestinum tenue.

ABSTRACT

Ibnu Thoriq Hidayat.24020113130135. Effect of Papaya Seed Water Extract (Carica Papaya
L.) Treatment on the Structure of Small Intestine of Female mice (Mus Musculus L.).
Supervised by Agung Janika Sitasiwi and Siti Miflichatun Mardiati
Papaya seed extract (Carica papaya L.) contains saponins, alkaloids, flavonoid, and tannins
which are commonly used as an ingredient of traditional medicine. The ethanol extract of papaya
seeds showed inhibitory reactions on jejunal contractions and was significantly irreversible. This
study aims to examine the effect of papaya seed water extract on the intestine structure of female
mice (Mus musculus L.). The Completely Randomized Design with 4 treatments namely P0
(distilled water), P1 (1.4 mg / 0.5 ml), P2 (3.5 mg / 0.5 ml) and P3 (7 mg / 0.5 ml) was used as
axperimental design. The treatment was given orally for 21 days. Feeding and drinking are done
in ad libitum. Small intestine was isolated as long as 2 cm from the stomach as long as 1 cm and
then made histological preparations by the paraffin method with 5 μm in thickness incision and
staining of Hemactosillin and Eosin (H&E). Measurements of villous length and diameter of
small intestine were performed in 3 incisions in every 3 histological small intestine preparations.
Data were analyzed by Anova test, followed by Duncan test with a significance level of 5%. The
analysis showed that the exposure of the test material had no significant effect (p> 0.05) on
diameter, villi length, and body weight. It could be concluded that the treatment of papaya seed
water extract for 21 days does not affect the structure of mice small intestine, so it is safe to use
as an ingredient of traditional medicine.
Keywords: Carica papaya, villi, small intestine.

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Ketersediaan

1508B21I

1508 B 21-i

Perpustakaan FSM Undip (Referensi)

Tersedia

Informasi Detail

Judul Seri

BIOLOGI

No. Panggil

1508 B 21-i

Penerbit

: ., 2021

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

-

Subjek

-

Info Detail Spesifik

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Pernyataan Tanggungjawab

Ibnu Thoriq Hidayat

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